Berberin
Za posledných 10 až 15 rokov je berberinu venovaná mimoriadna pozornosť zo strany biomedicíny. V rade štúdií bolo preukázané, že berberin vykazuje širokú škálu biologických aktivít a že jeho farmakologické účinky sú v súlade s jeho využitím v ľudovom liečiteľstve. Možnosti jeho využitia v modernej medicíne sú najmä v boji s bakteriálnymi hnačkami (Chen et al., 2014b), cukrovkou 2. typu (Han et al., 2011; Li et al., 2014), hypercholesterolémiou (Wang et al., 2014b), rôznymi zápalmi bakteriálneho a infekčného pôvodu (Chen et al., 2014a; Zhang et al., 2014), chorobami srdca (Lau et al., 2001) a neurodegeneratívnymi chorobami (Chen et al., 2014a ; Jiang et al., 2015).
Experimentálne bola preukázaná schopnosť berberinu potlačovať rast nádorových buniek pri rakovine pŕs (Tan et al., 2014; Xie et al., 2015), prostaty (Wang et al., 2012; Lu et al., 2015), slinivky brušnej (Leng et al., 2004) či leukémii (Liu et al., 2012).
Literatúra:
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- Han J, Lin H, Huang W. Modulating gut microbiota as an anti-diabetic mechanism of berberine. Med Sci Monit. 2011; 17(7): RA164-RA167.
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- Chen C, Yu Z, Li Y, Fichna J, Storr M. Effects of berberine in the gastrointestinal tract – a review of actions and therapeutic implications. Am J Chin Med. 2014b; 42(5): 1053-1070.
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- Leng SH, Lu FE, Xu LJ. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin. 2004; 25(4): 496-502.
- Liu J, Zhang X, Liu A, Liu S, Zhang L, Wu B, Hu Q. Berberine induces apoptosis in p53-null leukemia cells by down-regulating XIAP at the post-transcriptional level. Cell Physiol Biochem. 2013; 32(5): 1213-1224.
- Li Z, Geng YN, Jiang JD, Kong WJ. Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus. Evid Based Complement Alternat Med. 2014; 2014: 289264.
- Lu W, Du S, Wang J. Berberine inhibits the proliferation of prostate cancer cells and induces G0/G1 or G2/M phase arrest at different concentrations. Mol Med Rep. 2015; 11(5): 3920-3924.
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- Tan W, Li N, Tan R, Zhong Z, Suo Z, Yang X, Wang Y, Hu X. Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis. Anticancer Agents Med Chem. 2014; 15(1): 66-78.
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- Wang Y, Liu Q, Liu Z, Li B, Sun Z, Zhou H, Zhang X, Gong Y, Shao C. Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. Mutat Res. 2012; 734(1-2): 20-29.
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- Wang Y, Yi X, Ghanam K, Zhang S, Zhao T, Zhu X. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. 2014b; 63(9): 1167-1177.
- Xie J, Xu Y, Huang X, Chen Y, Fu J, Xi M, Wang L. Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway. Tumour Biol. 2015; 36(2): 1279-1288.
- Zhang Y, Li X, Zhang Q, Li J, Ju J, Du N, Liu X, Chen X, Cheng F, Yang L, Xu C, Bilal MU, Wei Y, Lu Y, Yang B. Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats. J Pharmacol Exp Ther. 2014; 349(3): 417-426.