Berberin

Za posledných 10 až 15 rokov je berberinu venovaná mimoriadna pozornosť zo strany biomedicíny. V rade štúdií bolo preukázané, že berberin vykazuje širokú škálu biologických aktivít a že jeho farmakologické účinky sú v súlade s jeho využitím v ľudovom liečiteľstve. Možnosti jeho využitia v modernej medicíne sú najmä v boji s bakteriálnymi hnačkami (Chen et al., 2014b), cukrovkou 2. typu (Han et al., 2011; Li et al., 2014), hypercholesterolémiou (Wang et al., 2014b), rôznymi zápalmi bakteriálneho a infekčného pôvodu (Chen et al., 2014a; Zhang et al., 2014), chorobami srdca (Lau et al., 2001) a neurodegeneratívnymi chorobami (Chen et al., 2014a ; Jiang et al., 2015).

Experimentálne bola preukázaná schopnosť berberinu potlačovať rast nádorových buniek pri rakovine pŕs (Tan et al., 2014; Xie et al., 2015), prostaty (Wang et al., 2012; Lu et al., 2015), slinivky brušnej (Leng et al., 2004) či leukémii (Liu et al., 2012).

Literatúra:

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  • Xie J, Xu Y, Huang X, Chen Y, Fu J, Xi M, Wang L. Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway. Tumour Biol. 2015; 36(2): 1279-1288.
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